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These studies replicated the roles of important AD or PD genes and pathways and identified shared alterations in cellular energy metabolism and stress response, mitochondrial ROS, inflammation, lipid signaling, protein folding, and protein degradation [176,177]

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Novel material-based approaches are also being investigated to advance pulmonary drug delivery, such as thin-film freezing, supercritical fluid technology, nano-in-micro particle systems, crystal-engineered microstructures, and porous drug carriers, all of which aim to improve drug stability, bioavailability, and pulmonary retention [209, 210]