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It also interacts with the NRF2 pathway: studies show that the MOTS-cNRF2 interaction can increase the expression of protective mitochondrial genes, enhancing the cells ability to cope with stress and damage

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Aluminum (Al) is known as an important neurotoxic compound, the physiological action of Al is not known already, and in high concentrations can lead to intoxication and cause neurotoxicity

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