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Safety, tolerability, and preliminary efficacy of the anti-fibrotic small molecule PRI-724, a CBP/-catenin inhibitor, in patients with hepatitis C virus-related cirrhosis: a single-center, open-label, dose escalation phase 1 trial

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conservative protocols remain at 50 mcg/day

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Overall, available data indicate that protein metabolism across the menstrual cycle undergoes subtle physiological modulation (Figure 5), with a tendency toward increased amino acid flux and oxidation during the luteal phase, while net anabolic capacity appears largely preserved