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EPA and DHA also activate the gene encoding the G-protein coupled receptor 120 (GPR120) which is expressed in inflammatory macrophages and in vivo when obese mice are supplemented with these PUFAs (isocaloric high fat diet containing 27% fish oil supplementation enriched with 50 and 100 mg of DHA and EPA, respectively, per mouse, per Day) [70]

[DOI] [PMC free article] [PubMed] [Google Scholar] 153.Chiu YJ, Lin CH, Lin CY, Yang PN, Lo YS, Chen YC, Chen CM, Wu YR, Yao CF, Chang KH, Lee-Chen GJ

Youre asking are you more likely to have a proper mitochondrial function and feel good if you have more mitochondria and a robust antioxidant system

Given their broad CYP liabilities and limited binding improvement, the oxime modification appears less attractive for this series

Redox Biology 26, 101254