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In the worst cases of C

Chem Biol 11: 639646 Sedensky MM, Siefker JM, Morgan PG (2001) Model organisms: new insights into ion channel and transporter function

This leads to an elevation in the level of reactive oxygen species (ROS) in neurons, which subsequently results in dysfunction of the ubiquitin-proteasome system (Martin et al., 2012)
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Michael Gold, a Nashville dermatologic surgeon, in this RealSelf Q&A
