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Although the maximum plasma concentration is lower when compound 2 is administered PO (0.77 M) instead of IP (4.8 M), it is still 4.3-fold higher than LD 50 for ex vivo NTS determined in the commonly used 72 h assay, also indicating that TGR inhibitor 2 is orally bioavailable and the initial prediction of oral bioavailability based on the Lipinski et al

doi:10.1007/s10558-010-9092-1

doi: 10.1016/j.freeradbiomed.2007.04.016

Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR, Gastroenterology PPCotACo: ACG clinical guideline: diagnosis and management of idiosyncratic drug-induced liver injury