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Recently, the recognition that 2-ODDs participate in histone and DNA modifications have resulted in the suggestion that ascorbate could regulate epigenetic control of gene expression

All cells except HepG2 were maintained in RPMI 1640 media (Gibco) containing 2mM glutamine, 10% fetal bovine serum, 1% penicillin and streptomycin

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the cytotoxic agents exemplified with this strategy include anthracyclines, taxanes, mitomycin C, and the auristatins
