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Nevertheless, due to adverse effects of long-term dopamine agonist therapy, an exploration of alternative strategies to medical therapy is warranted, such as surgery
ATP is the mediator of this death mode switching and initiates necrotic apoptosis when the amount of ATP available in a cell is less than 50% [87]
2) pyruvate / oxoglutarate decarboxilation to thiamine phyrophosphate by pyruvate / oxoglutarate dehydrogenase (PDH / OGDH) that is required for the formation of acetyl / succinyl coenzyme A (CoA)
Experiments on Fh1-deficient cells incubated with 13 C 5 -glutamine revealed that succinicGSH is excreted in the media (Fig
Daley, B
