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These results suggested that GRFT does not bind to SPLCV

Here, catecholamines facilitate widespread central sensitization and dysregulate descending inhibitory pathways, contributing to chronic pain in the absence of clear tissue or neural damage

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Lipid peroxidation generates hydroperoxides as well as endoperoxides, which undergo fragmentation to produce a broad range of reactive intermediates called reactive carbonyl species (RCS) (Figure 4) with three to nine carbons in length, the most reactive being ,-unsaturated aldehydes [4-hydroxy-trans-2-nonenal (HNE) and acrolein], di-aldehydes [malondialdehyde (MDA) and glyoxal], and keto-aldehydes [4-oxo-trans-2-nonenal (ONE) and isoketals] [24]