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[DOI] [PubMed] [Google Scholar] 78.Lee-Young R.S., Ayala J.E., Hunley C.F., James F.D., Bracy D.P., Kang L., Wasserman D.H

Decreased serum IGF-1/IGFBP-3 Molar ratio is associated with executive function behaviors in type 2 diabetic patients with mild cognitive impairment
Two reviews on neurodegenerative diseases support the ANLS hypothesis and its role in neuropathologynamely, lactate is neuroprotective and a therapeutic agent

This selectivity limitation may be especially relevant for repurposing inhibitors of other proteases for 3CL protease or applying compounds with covalent warheads designed to target cysteine proteases