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doi: 10.1007/s12892-019-0138-0 40 CakmakciR.TuranM.GulluceM.SahinF

Mechanistically, there is a negative correlation between KLF2 and GPX4, and KLF2 deficiency increases the level of GPX4 and inhibits ferroptosis, promoting the invasion and migration of renal cancer cells, which can be reversed by overexpression of GPX4, 150 indicating that promoting ferroptosis of cancer cells may be a promising strategy for the clinical treatment of advanced RCC

Taken together, the literature indicates that while both CHAC1 and CHAC2 participate in related biological processes, their different structural and regulatory properties suggest complementary rather than redundant functions

Microcirculatory oxygenation and shunting in sepsis and shock
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