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While deficiencies of nutrients essential for one-carbon metabolism may be causing NAFLD due to decreased methyl-donor production or decreased DNA synthesis, other hypotheses are possible

Ann Thorac Surg 58(4):12401246 Zhang SF, Li LZ, Zhang W, Guo JR, Liu FF, Ma K et al (2020) Association between plasma homocysteine levels and subclinical hypothyroidism in adult subjects: a meta-analysis

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Finally, behavioral and energy-balance mechanisms provide a dynamic interface between internal metabolic regulation and the external nutritional environment
