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13,14 In recent decades, nanosystems development has been at the top of the list of priorities of drug delivery researchers

(Haapasalo et al., 2003) analyzed 433 cases of astrocytoma and showed that the expression of thioredoxin reductase-1 (TrxR1) was upregulated in more than 66% of cases, which was significantly associated with relatively high proliferative activity and poor prognosis

Ciavattini et al., 2016)

Research indicates it can cross the blood-brain barrier freely and survive intestinal passage with some retained activity
Han et al., 2020
