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Cell cultures (150 cm 2 at 80% confluence) were trypsinized and collected with lysate buffer (trichloroacetic acid 0.1 g/L, hydrochloric acid 0.774 M, mercaptoacetic acid 30 mM) to give 100 mg of cells for 400 L buffer

By stabilizing drug bioavailability while reducing neutrophil activation, pro-inflammatory cytokine secretion, and osteoclast activity, the formulation minimizes gastrointestinal toxicity, offering superior efficacy in managing gout-related pain, joint destruction, and systemic complications compared to conventional oral therapies (Li Z

GAT-1, GABA transporter-1

Compagnucci AB, Perroud HA, Batalles SM, Villavicencio R, Brasca A, Berli D, Pezzotto SM