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Description
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They retain the ability to interact with biological targets and produce similar biological effects
That can slow how the dose is used and is a known issue, particularly in women and larger patients where there is more tissue to pass through
80 MPO inhibition has been studied in a chronic guinea pig model of cigarette smoke-induced emphysema using 2-thioxanthine (AZ1), an MPO inhibitor developed by AstraZeneca
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