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Description
The following antibodies were used: i) cleaved poly(ADP-ribose) polymerase-1 (cPARP) (Cat# ab32064, clone E51, Abcam, Cambridge, UK) to assess cell death
Notably, ART-induced cell death was reversed by ferroptosis inhibitors ferrostatin-1 (Fer-1) and deferoxamine (DFO)
This approach addresses one of the major challenges in peptide therapy for bone healing: getting enough of the active compound to the fracture site
Therefore, it is important we know both what hinders glutathione production and what supports it
This isnt about masking painits about communicating with your biology to rebuild whats been lost
