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Perioperative analgesic studies in humans are currently few, with some studies failing to show benefit, and others demonstrating an opioid-sparing effect

An ideal strategy should integrate imaging such as quantitative MRI parameters, fluid aspiration measuring MDA, 4-HNE, iron metabolism indicators, and GPX4-related protein/nucleic acid levels, and advanced omics analyses to build a comprehensive risk assessment system for predicting ferroptosis activity and treatment response (Lotz et al., 2013)

Glutathione also contains sulfur chemical groups, which help bond free radicals and heavy metals and remove them

Protein S -nitrosylation and cancer

10.1016/0167-4889(87)90200-x 218 ShannonM