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Int J Radiat Oncol Biol Phys 116(3):533-543, 2023

1,4 Cobalamin deficiency leads to various clinical and metabolic consequences, including vomiting, diarrhoea, weight loss, failure to thrive, nerve disorders, immunodeficiency, and intestinal changes including poor absorption of nutrients and vitamins (including cobalamin itself)

This condition results in decreased mobility, higher medical costs, and increased mortality rates

Groups at Yale University tested this approach with their lipid nanoparticle (LNP)-mRNA vaccines encoding the full-length spike of SARS-CoV-2 Delta, SARS-CoV-1, and MERS-CoV