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TMAO synergizes with LPS to enhance the activation of NF-B in DCs and macrophages, increase the production of pro-inflammatory cytokines, and impair the function of Tregs

Ghanem and co-workers reported similar observations of increased antioxidant activity and improved blastocyst quality by way of higher embryo development rate and fewer number of apoptotic cells after supplementing LC (1.5 mM, equivalent to 0.3 mg/mL) in culture media of bovine blastocyst during the pre-implantation stage [67]