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Toll-like receptors 7 and 9 regulate the proliferation and differentiation of B cells in systemic lupus erythematosus

HW: Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writingoriginal draft, Writingreview and editing

Zhang, Z., Wang, Y., Zhang, N

Target protein levels were normalized to their respective loading controls (-actin or Histone H3) Pharmacological Interventions In Vitro Drug Treatments PC12 cells were exposed to pharmacological agents during oxygen-glucose deprivation/reperfusion (OGD/R) as follows: GPR68 activation: 10 M MS48107 (MedChemExpress, Cat No.HY-134494) in culture medium was administered throughout the OGD/R process, based on preliminary dose-response experiments showing maximal Akt phosphorylation at this concentration

GCS knockdown significantly reduces the MDR1 expression, a gene that encodes for ABC transporter protein [137,138]