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3) extended release (Timespan) tablets As illustrated in Figure 2, the dosage and frequency of dosing should be adjusted to the needs of the individual patient: Timespan slow release: one to three 180 mg Timespan extended release tablets are typically taken before bedtime

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Cell Chem Biol 27:420435

These include the 2-oxoglutarate dehydrogenase (-ketoglutarate dehydrogenase) complex (OGDC), and fumarate hydratase (fumarase)