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IGF-1 binding to the cysteine-rich domain of the subunits leads to sequential phosphorylation of Y1135, Y113, and Y1136 residues of the subunit which alters the structure of the chain, thereby turning on tyrosine kinase activity ( IGF-1 IN EMBRYONIC AND POSTNATAL SKELETAL DEVELOPMENT CONSEQUENCES OF IGF-1 GLOBAL DEFICIENCY IGF-1 is a major anabolic signal for both embryonic and postnatal skeletal development

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