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These compounds are often excreted in the urine in the form of free metal ions or water-soluble complexes (Mjos and Orvig, 2014)

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and site-specific inhibitors (S1QELs) can suppress this O 2 /H 2 O 2 output without affecting basal respiration, demonstrating that the site of generation dictates specific signaling outcomes [24, 72]

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