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Abundant cyt c was shown to translocate to the nucleus prior to caspase activation in the cytosol during the early phase of apoptosis (Nolin et al., 2016)

10.1002/ejhf.2810 53 GrandiF

Moreover, luteolin has been shown to interfere with MAPK/IL-1 signaling and IL-36 release in neutrophilic asthma models, suggesting broader immunomodulatory effects relevant to chronic lung diseases, including fibrosis [143]

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These results show that the HAW oral treatment, together with restoring the ROS levels at both the systemic and organ levels, led to the normalization of both the mitochondrial membrane potential and the mitochondrial superoxide levels induced by H 2 O 2 treatment, reaching levels comparable to the control mice