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Although HIF-2 has biochemical characteristics similar to those of HIF-1, the metabolic role of HIF-2 in a low-oxygen environment is relatively unknown 68

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however, the safety profile of rhGH in children and adults is good Current innovative treatment approaches relate to personalizing conventional rhGH, developing long-acting GH preparations, the prospect of gene therapy, GHGH receptor antagonists and, potentially, new indications Abstract Growth hormone (GH) research and its clinical application for the treatment of growth disorders span more than a century

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Kroetz DL, Yook P, Costet P, Bianchi P, Pineau T (1998) Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes