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Considering the indirect nature of neurovascular coupling that gives rise to BOLD contrast [67], it is worth noting that a global reduction in CBF has been reported in ME/CFS patients when compared to healthy controls [68]

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doi: 10.1111/j.1939-165X.2009.00124.x

However, it is crucial to accurately diagnose melanocytic tumors, as prognosis and therapy vary greatly between the differentials

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