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ALDHs are overexpressed in subpopulations of cancer cells with stem-like features, where they are involved in several processes including cellular proliferation, differentiation, detoxification and survival, participating in lipids and amino acid metabolism and retinoic acid synthesis

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Mason, Free radical metabolites of L-cysteine oxidation

Other factors that have been associated with an increased risk of thyroid cancer include a family history of the disease, the presence of certain variants in susceptibility genes, such as WD repeat domain 77 ( WDR77 ), BRO1 domain and CAAX motif containing ( BROX ), hyaluronan binding protein 2 ( HABP2 ), and SLIT-ROBO Rho GTPase activating protein 1 ( SRGAP1 ) for papillary thyroid cancer (PTC), and forkhead box E1 ( FOXE1 ) for both PTC and follicular thyroid cancer (FTC), and certain benign thyroid conditions such as goiter and thyroid nodules [2,3]

Valencia-Quintana R