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Studies have suggested that the leucine-rich repeat kinase 2 (LRRK2) protein may be specifically involved in regulating Drp1-mediated mitochondrial fission

Salmanian AH, Siavoshi F, Akbari F, Afshari A, Malekzadeh R

The escalation schedule built into the clinical protocol reflects the tolerability profile of combined receptor activation

These CMs had a particle size of approximately 250 nm and sustained the release of rhBMP-2 for approximately 20 days

For example, alternating weekly between 7.5 mg and 5 mg provides an average dose of 6.25 mg, which may maintain results that previously required continuous 7.5 mg dosing