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Description
The oncogenic transcription factor c-Jun is reported to elevate the expression of mitochondrial glutaminase by directly binding to its promoter region in breast cancer cells [12]
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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the two most common residual products of various cellular processes, including aerobic metabolism [37]
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The NLRP3 inflammasome is also activated by mtDNA and mtROS, further contributing to neuroinflammatory cascades [223]
