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The analysis of fibroblasts and iPS-derived midbrain neurons from BPAN (Table 1) patients revealed that the loss of function of WDR45, involved in autophagic fluxes, had consequences on the mitochondrial network

A review of the medical examination data from 25 autistic children found that 53% of these patients had increased pyruvate levels, 76% had elevated blood lactate, in 20% of them the lactate/pyruvate ratio in fibroblasts was increased, and 42% were presented with atypical results of urine organic acid analysis [72]

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