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The main function of GST is its participation in the antioxidant system through its ability to reduce organic hydroperoxides to alcohols using GSH as the cosubstrate [85]: Via Se-independent glutathione-peroxidase activity, GST reduces hydroperoxides of polyunsaturated higher fatty acids, phospholipids, and cholesterol [94, 95]

Only aldolase A (ALDOA) was found to be both less oxidized on its potentially critical cysteine (Cys 339 ) and at the same time to be more abundant, which may corroborate its critical role in cancer survival and metastasis 41

These findings emphasize that renal function should always be assessed when measurements of serum MMA are used, especially in the elderly

NAC is a well-studied, Food and Drug Administration (FDA)-approved drug, with a favorable safety profile in neonates, giving these findings significant translational potential in the face of the opioid epidemic and rising rates of NAS after exposure to opioids in utero