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In PHT, the autophagic process is severely impaired through an IL-1-mediated pathway [145]

Ofori et al., 2022)

The aggregation and denaturation that follow repeated freeze-thaw cycles will degrade both peptides, and unlike the lyophilized state, the damage is not reversible

doi: 10.15585/mmwr.mm7215a1 2

Metabol, Pediatric, Syst Ophthalmol