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For the assessment of mitochondrial glutathione redox potential, the MB -neuron specific GAL4 driver 201Y-GAL4 was used to express UAS-mito-roGFP2-Grx1 in WT and Cdk5-KO conditions

These solidified aggregates are irreversible, and usually toxic

DK, LB, and SS collected and analyzed the pathological samples

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Further, the study was also designed to test the homocysteine theory of depression, ie, circumventing the patients genetic inability to metabolize B vitamins by administering the metabolized forms in an optimal preparation for CNS availability would lower homocysteine, increase monoamine production, and facilitate clinical improvement