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The top five players Medidata, IQVIA, Parexel, Fortrea, and Covance collectively hold approximately 46% of the 2025 global market, reflecting a competitive structure in which technology platform breadth, regulatory validation depth, and global site network scale provide material advantages in securing large-pharma sponsor mandates
However, serum blood levels of B12 begin to drop, with the majority likely being active B12 (holoTC)
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Mller et al., 2013)
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