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Here, we synthesized a potent and selective TGR5 agonist OM8 with high distribution in intestinal tract and investigated its effect on IEC apoptosis and UC treatment

However, the potential of these C-terminal inhibitors and their molecular mechanisms remain elusive

176 Mice lacking ZIP4 exhibit disrupted villus integrity, highlighting the significance of ZIP4 in preserving the architecture of the intestinal epithelium

1) Decipher cell type-specific ferroptosis regulatory networks: Use integrated single-cell multi-omics (scRNA-seq, Single-cell Assay for Transposase-Accessible Chromatin with High-throughput Sequencing (scATAC-seq), and single-cell metabolomics) to map ferroptosis-related gene expression, chromatin accessibility, and metabolite profiles across renal cell types in health and disease

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