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Clostridial toxins A (TcdA) and B (TcdB) utilise TJ components as receptors, specifically the nectin-3 component of adhesion junctions, which leads to downstream cytoskeletal disruptions and cell death (Roxas and Viswanathan 2018)

Therefore, Penders explicitly rejected the hypothesis that H directly reacts with ONOOH or inhibits tyrosine nitration, clarified related controversies, and pointed out that the antioxidant effect of H is more likely achieved through other mechanisms (such as signal regulation) rather than through direct scavenging of reactive oxygen/nitrogen species (Penders et al., 2014)

Recent advances in data-independent acquisition mass spectrometry (DIA-MS) based proteomics have made it possible to simultaneously identify and quantify thousands of proteins in plasma across a large dynamic range, significantly enhancing the discovery of potential biomarkers and regulators of disease 21

Cancers affecting the digestive system, such as those of the esophagus, stomach, liver, pancreas, and intestines, are among the top causes of cancer-related mortality, with limited available treatments [181]

Clients should be instructed to immediately report any symptoms suggestive of agranulocytosis, such as fever or sore throat