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Impaired FAD-dependent enzyme activity is also detrimental to bloodbrain barrier (BBB) integrity, leading to downregulation of tight-junction proteins such as claudin-5 and occluding, increased permeability, and enhanced peripheral immune infiltration

Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis

For example, mouse studies on the gutbrain axis have been pivotal in uncovering the role of SCFAs in microbiotagutbrain signaling

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They also affect hematopoiesis (Maines and Trakshel, 1992b