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Archives of Biochemistry and Biophysics 429, 7180

26 , 27 The acidic pH facilitates enzymatic activities, limits cellular water loss, acts as defense against harmful foreign bodies such as bacteria, and maintains the integrity and adhesion of the SC

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Results Peripheral blood mononuclear cells from DADA2 patients show increased levels of basal cell death but reduced induction of necroptosis in vitro We isolated mononuclear cells (PBMCs) from the peripheral blood of ten DADA2 patients (Supplementary Table S1) and analysed their viability compared with PBMCs from healthy donors