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Cancer Evolution

CNS Hcy is associated with brain fog that may be mediated by CVOs (Oner et al., 2023)

Moreover, environmental factors, such as heavy metals, also contribute to excessive ROS

There is also a lack of data regarding the contribution of extranuclear vs nuclear ER actions, as well as ligand- vs nonligand-mediated functions of its receptors in these tissue-specific actions of E2

So I arrive at a model where elongation happens in one compartment, and then the elongated fibrils must be trafficked inward to an acidic compartment where pH-dependent proteases fragment them, and then the fragmented fibrils must re-emerge to undergo elongation again