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However, the levels of aspartate in human plasma are low, and the SLC1A3 transporter protein does not effectively transport aspartate

A combination of sorafenib plus lapatinib (an ERBB1/2/4 inhibitor) act synergistically, killing glioblastoma cells by autophagy (ER stress) and apoptosis (via death receptors and mitochondria), inactivating ERK, AKT, mTOR, p70, and S6K, while decreasing the levels of Mcl-1 and Bcl-xL

This is attributed to distribution of the administered drug between the central compartment and tissue (peripheral compartment)
Microglia in the A-related subcluster showed increase in the expression of ferroptosis-related genes, while microglia in tau pathology-related subcluster showed decrease in the expression of these genes
