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Data that remained non-normally distributed and/or heteroscedastic after log transformation were analyzed (not log-transformed, but still 1e13-transformed) with a KruskalWallis test, while normally distributed and homoscedastic data were analyzed with a one-way ANOVA, performed on the log-transformed data as necessary

Continue increasing by 0.25 to 0.5 mg every 4 weeks until reaching the target dose or maximum tolerated dose

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TB-500 is the rate-limiting component due to its larger size