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doi: 10.1074/jbc.M112.390369

Topical Electrophilic Nitro-Fatty Acids Potentiate Cutaneous Inflammation

The HPV16 E7 oncoprotein directly suppresses the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, significantly reducing the expression of genes that encode type I interferon and pro-inflammatory proteins, hence facilitating immune evasion in several HPV-related tumors in murine models (Luo et al., 2020)

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