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Mechanistically, Arctigenin downregulated CPT1-mediated FAO, which further inhibited nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome assemblies in macrophages (Qiao et al., 2020)

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It is also important to note that a prior randomized, placebo-controlled, double-blind study of LAC treatment for probable AD patients showed that administration of LAC was associated with lower AD-related deterioration as assessed using the clinical dementia rating scale and mini-mental scale examination in those subjects younger than 65 years [65, 66]

Die positiven Effekte auf den Glukosestoffwechsel lassen sich mglicherweise auch darauf zurckfhren, dass L-Carnitin Entzndungsmediatoren wie CRP, IL-6 und TNF- im Blut reduziert 6 und den Leberstoffwechsel positiv beeinflusst, was sich anhand der verbesserten Werte fr Leberenzyme (ALAT, ASAT und GGT) im Blut zeigen lsst