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Cobalamin deficiency can cause a host of symptoms, including: Tiredness and weakness Nausea Decrease in appetite/weight loss Poor memory and concentration Sore mouth/tongue Numbness/tingling in limbs Vision problems and balance issues Heart palpitations Depression and irritability

40 Addittionally, homocysteine has several procoagulant properties including the decrease of antithrombin III binding to endothelial heparan sulfate, increase of affinity between lipoprotein(a) and fibrin, induction of tissue factor activity in endothelial cells, and inhibition of inactivation of factor V by activated protein C

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