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Conventional therapeutic approaches, including aminosalicylates, corticosteroids, immunosuppressants, and biological agents, face significant limitations including premature drug release, systemic toxicities, narrow therapeutic windows, and inadequate colonic accumulation

However, interpretation of these signatures may be confounded by kidney function and medication use, and clinical translation will require rigorous external validation, particularly in prospective cohorts and trials specifically designed for DKD

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We further investigated the effect of L- carnitine on improvement of KOA in obese women on low calorie diet