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There are many factors to consider in the hypothalamic regulation of food intake, and the interactions between adiposity and the central neuropeptidergic cascade downstream of leptin are increasingly being studied

In addition, irreversible inhibitors of PAD4 (e.g., F- and Cl-amidine) covalently bind to Cys645 at the PAD4 active site (212), significantly reducing histone citrullination and inhibiting the formation of NETs (213)

doi: 10.1158/0008-5472.Can-11-0025 213 TrevenPPaveljekDBogovi MatijaiBMohar LorbegP

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