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When exogenous growth hormone enters the system, it binds the hGH receptor, activates JAK2/STAT5 signalling, drives IGF-1 production in the liver, stimulates longitudinal bone growth, and simultaneously activates lipolysis through a parallel pathway

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NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools
