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Some ME/CFS patients have displayed elevated BAFF, but the gene expression of the BAFF receptor (TNFRSF13C) has been shown to be reduced in ME/CFS patients, suggesting that the elevated serum BAFF is a compensatory mechanism
However, concerns remain regarding the long-term efficacy of iPS cell-derived RPE therapies, particularly due to the risk of oncogenic mutations and tumorigenesis reported in both preclinical models and clinical observations 47,48

J., Brzozowski T