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First, CIPN is associated with hyperactivity and hyperexcitability in several brain regions including the PAG, thalamus, ACC, S2, and insula, which makes sense as they are part of well-known circuitry related to sensation and perception including pain (Reddan and Wager, 2018)

doi: 10.3389/fncel.2020.00274 Received 22 May 2020 Accepted 03 August 2020 Published 27 August 2020 Volume 14 - 2020 Edited by Alessandro Tozzi, University of Perugia, Italy Reviewed by Baej Misiak, Wrocaw Medical University, Poland

After a 9-month intervention diet, 20 of the 37 dogs with DCM eating NT diets at baseline (54%) were alive and had a follow-up sample analyzed in contrast to 2 of 8 dogs with DCM eating T diets at baseline (25%

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These findings raise the possibility of a gutretina axis, in which dietary components may influence retinal disease via immune-metabolic signaling ( Despite these encouraging developments, the clinical translation of dietary supplementation remains hampered by several limitations