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While high-carbohydrate intake can stimulate hepatic de novo lipogenesis and increase liver fat in overfeeding conditions, these effects are reversible with calorie restriction and do not imply permanent hepatic dysfunction (Basaranoglu et al., 2015)

doi: 10.3389/fphar.2024.1446554 Received 10 June 2024 Accepted 29 July 2024 Published 09 August 2024 Volume 15 - 2024 Edited by Gang Chen, Shenyang Pharmaceutical University, China Reviewed by Yi Tao, Zhejiang University of Technology, China Shihao Zheng, Beijing University of Chinese Medicine, China Updates Copyright 2024 Sun, Zhang and Xue

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